Astrocytes influence pain pathways in the spinal cord
Astrocytes mediate priming of spinal nociceptive circuits
This study looks at how certain brain cells called astrocytes influence pain after surgery in newborns, with the goal of finding new ways to help manage pain for those who have had medical procedures.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11003965 on NIH RePORTER |
What this research studies
This research investigates how astrocytes, a type of brain cell, affect pain pathways in the spinal cord, particularly after surgical procedures in newborns. It focuses on understanding how these cells can change the way pain signals are processed, potentially leading to increased pain sensitivity later in life. By examining the communication between astrocytes and nerve cells, the research aims to uncover new mechanisms that contribute to pain amplification. The findings could help identify new treatment targets for managing pain in individuals who have undergone invasive medical procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults who have undergone invasive surgical procedures during infancy.
Not a fit: Patients who have not experienced any surgical procedures or those with chronic pain from non-surgical causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce chronic pain in patients who have experienced early life surgeries.
How similar studies have performed: Other research has shown promising results in understanding the role of astrocytes in pain modulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Yoo, Judy Joonhi — University of Cincinnati
- Study coordinator: Yoo, Judy Joonhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.