Astrocytes and their role in HIV-related brain issues.
Astrocyte-derived exosomes contribute to HIV neuropathogenesis.
['FUNDING_R21'] · UNIVERSITY OF PUERTO RICO MED SCIENCES · NIH-10652615
This study is looking at how certain brain cells called astrocytes might affect thinking and memory problems in people with HIV, by exploring tiny particles they release that help communicate with the body, to find new ways to support brain health.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PUERTO RICO MED SCIENCES (nih funded) |
| Locations | 1 site (SAN JUAN, UNITED STATES) |
| Trial ID | NIH-10652615 on ClinicalTrials.gov |
What this research studies
This research investigates how astrocytes, a type of brain cell, contribute to cognitive impairment in people living with HIV. It focuses on the role of exosomes, which are small particles released by astrocytes, in communicating between the brain and the rest of the body. The study examines the relationship between these exosomes, inflammation, and metabolic processes in the brain, particularly in patients experiencing cognitive difficulties. By understanding these mechanisms, the research aims to uncover potential therapeutic targets for improving brain health in individuals with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV, particularly those experiencing cognitive impairment or at risk of developing such issues.
Not a fit: Patients who are not living with HIV or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive impairment in people living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding the role of astrocytes in neurological conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN JUAN, UNITED STATES
- UNIVERSITY OF PUERTO RICO MED SCIENCES — SAN JUAN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOJNA, VALERIE — UNIVERSITY OF PUERTO RICO MED SCIENCES
- Study coordinator: WOJNA, VALERIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.