Assessing tools to prevent psychosis in at-risk individuals
Official title: ProCAN: Psychosis Risk Outcomes Compound Assessment Network
Funded at Yale University · NIH-11117166 · Data updated 2026-11-12
This study is looking for ways to help people who are at high risk of developing psychosis by finding new tools and treatments that can prevent these disorders from starting, so they can feel better and function well in their daily lives.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 14, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $16,589,886 |
| NIH project number | 5U01MH137298-02 |
| Project ID | NIH-11117166 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents and young adults identified as being at clinical high risk for developing psychotic disorders.
✕Less likely to help
Patients who are not at risk for psychosis or who have already developed psychotic disorders may not benefit from this research.
What this research studies
This research focuses on individuals at clinical high risk for psychosis, aiming to develop and validate tools that can help prevent the onset of psychotic disorders. By collaborating with various partners, the project seeks to identify biological, cognitive, and clinical measures that can be used in drug development. Patients will be monitored and assessed using these measures to determine their effectiveness in improving symptoms and overall functioning. The goal is to create a robust infrastructure that supports the development of new treatments for those at risk.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing psychosis in individuals at high risk, improving their quality of life.
How similar studies have gone: Previous initiatives like the Accelerating Medicines Partnership® Schizophrenia Observational Study have shown promise in developing tools for understanding and treating psychosis risk.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Woods, Scott W — Yale University
- Study coordinator: Woods, Scott W
Related research
Other NIH-funded projects on the same topics.
-
Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
-
Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
-
Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
-
Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
-
Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.