Assessing the stability of plasma and serum samples after thawing
Plate reader assays to forensically assess exposure of plasma and serum to thawed conditions
This study is looking at how thawing blood samples affects important cancer markers, and it aims to create an easy and affordable test to see if these samples have been stored properly, which could help make cancer research more accurate and trustworthy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10861899 on NIH RePORTER |
What this research studies
This research investigates how exposure to thawed conditions affects the stability of important cancer-related biomarkers in plasma and serum samples. By developing a new, cost-effective assay, the study aims to provide a quick estimate of how long these samples have been improperly stored at room temperature. This could help improve the quality of biospecimens used in clinical research, ultimately leading to more reliable results. The methodology involves analyzing small volumes of plasma or serum to determine their integrity after thawing.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have provided plasma or serum samples for cancer-related studies.
Not a fit: Patients whose samples have not been exposed to thawed conditions or who do not have archived plasma or serum samples may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate cancer biomarker discovery and improve the reliability of clinical research outcomes.
How similar studies have performed: Similar research has shown promise in improving biomarker stability assessments, but this specific approach is relatively novel.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Borges, Chad R — Arizona State University-Tempe Campus
- Study coordinator: Borges, Chad R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.