Assessing the safety of chemicals without animal testing
Official title: Triage of Developmental and Reproductive Toxicants using an In vitro to In Vivo Extrapolation (IVIVE)-Toxicokinetic Computational modeling Application
Funded at Scitovation, LLC · NIH-11184606 · Data updated 2026-11-12
This study is working on new ways to check if environmental chemicals are safe for people, especially when it comes to their effects on development and reproduction, by using computer models instead of animal testing, so researchers and regulators can better understand the risks these chemicals might pose.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scitovation, LLC NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | July 7, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $973,277 |
| NIH project number | 2R44ES035657-02A1 |
| Project ID | NIH-11184606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals concerned about chemical exposure during pregnancy or those involved in regulatory assessments of chemical safety.
✕Less likely to help
Patients who are not affected by chemical exposures or those not involved in reproductive health may not benefit from this research.
What this research studies
This research focuses on developing new methods to evaluate the safety of environmental chemicals, particularly those that may affect development and reproduction. By using advanced computational models, the study aims to predict how these chemicals behave in the human body based on laboratory tests, reducing the need for traditional animal testing. The project will create a user-friendly tool that allows researchers and regulators to assess potential risks associated with chemical exposure more effectively.
Why it matters
Potential benefit: If successful, this research could lead to safer chemicals and improved public health by providing reliable assessments without relying on animal testing.
How similar studies have gone: Other research has shown promise in using computational models for safety assessments, indicating that this approach could be a significant advancement in the field.
Where this research is happening
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Scitovation, LLC
Durham, United States Active
Researchers
- Principal investigator: Moreau, Marjory — Scitovation, LLC
- Study coordinator: Moreau, Marjory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.