Assessing the effects of chemicals using a tiny worm model.
The Next-Generation Developmental and Reproductive Toxicology (DART) Assay using High-Content Analysis of Genetically Diverse C. elegans Populations
This study looks at how different chemicals impact the growth and reproduction of tiny worms, helping us learn how various groups of these worms react to harmful substances, which could lead to safer products and a healthier environment for everyone.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vivoverse, LLC NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-10894121 on NIH RePORTER |
What this research studies
This research investigates how different chemicals affect the development and reproduction of the microscopic worm Caenorhabditis elegans, which is a model organism. By using genetically diverse populations of these worms, the study aims to better understand how various groups may respond differently to environmental toxins. The approach focuses on reducing the reliance on traditional animal testing methods, aligning with ethical standards and regulatory changes. Patients may benefit from safer chemical products and improved environmental health as a result of this research.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals living in communities at higher risk of exposure to environmental chemicals, particularly those under 21 years old.
Not a fit: Patients who are not affected by environmental toxins or who do not live in areas with significant chemical exposure may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer chemical products and better protection for vulnerable populations from environmental toxins.
How similar studies have performed: Other research has shown promise in using alternative models like C. elegans for toxicology assessments, indicating that this approach is gaining traction in the field.
Where this research is happening
Austin, United States
- Vivoverse, LLC — Austin, United States (Active)
Researchers
- Principal investigator: Hegarty, Evan — Vivoverse, LLC
- Study coordinator: Hegarty, Evan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.