Assessing the effects of a mixture of common environmental chemicals on health.
In Vivo Assessment of an Equimolar or Environmentally Relevant Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) Mixture
This study is looking at how a group of chemicals called PFAS, which are often found in the environment, might affect the thyroid and liver health in rats over 28 days, and it aims to help us understand the possible health risks these chemicals could pose to people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Centers/pub Hlth Res & Evaluatn NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11216053 on NIH RePORTER |
What this research studies
This research investigates the health impacts of a mixture of perfluoroalkyl and polyfluoroalkyl substances (PFAS) using rat models. It focuses on understanding how these chemicals, often found in the environment, affect the thyroid and liver functions over a 28-day exposure period. The study aims to evaluate the combined effects of multiple PFAS, which have not been thoroughly assessed together, to better understand their cumulative risk on health. By analyzing the differences in responses between male and female rats, the research seeks to provide insights into the potential health risks posed to humans.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with known exposure to PFAS through environmental sources or those concerned about the health effects of these chemicals.
Not a fit: Patients who are not exposed to PFAS or those without related health concerns may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessments and guidelines for human exposure to PFAS mixtures, ultimately enhancing public health safety.
How similar studies have performed: While there have been numerous studies on individual PFAS, this research is novel in its approach to assess the combined effects of multiple PFAS, which has not been extensively tested before.
Where this research is happening
Columbus, United States
- Battelle Centers/pub Hlth Res & Evaluatn — Columbus, United States (Active)
Researchers
- Principal investigator: Fallacara, Dawn — Battelle Centers/pub Hlth Res & Evaluatn
- Study coordinator: Fallacara, Dawn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.