Assessing sudden death risk in patients with mitral valve prolapse using cardiac imaging and blood tests
Official title: Sudden Death Risk Assessment and Mechanistic Insights in Arrhythmic Mitral Valve Prolapse Using Cardiac MRI and Circulating Proteomic Biomarkers
Funded at Methodist Hospital Research Institute · NIH-10982190 · Data updated 2026-11-12
This study is looking at how mitral valve prolapse might increase the risk of sudden cardiac death, and it aims to find specific blood markers that could help identify patients who are at higher risk, so we can improve how we monitor and care for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 5, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,518,070 |
| NIH project number | 1R01HL171150-01A1 |
| Project ID | NIH-10982190 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with mitral valve prolapse, particularly those experiencing arrhythmias or other cardiac symptoms.
✕Less likely to help
Patients without mitral valve prolapse or those who do not exhibit any cardiac symptoms may not benefit from this research.
What this research studies
This research investigates the risk of sudden cardiac death in patients with mitral valve prolapse (MVP), a condition affecting a significant portion of the population. The study aims to deeply analyze the characteristics of MVP patients and identify specific blood biomarkers that could indicate a higher risk for dangerous heart rhythms. By utilizing advanced cardiac MRI and proteomic analysis, the research seeks to develop a predictive model for sudden cardiac death in these patients. This approach could lead to better screening and management strategies for those at risk.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and treatment of patients with mitral valve prolapse who are at risk for sudden cardiac death.
How similar studies have gone: Previous research has indicated a potential link between mitral valve prolapse and sudden cardiac death, but this study aims to explore this connection in greater depth using novel methodologies.
Where this research is happening
-
Methodist Hospital Research Institute
Houston, United States Active
Researchers
- Principal investigator: Shah, Dipan J. — Methodist Hospital Research Institute
- Study coordinator: Shah, Dipan J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.