Assessing new treatments for stroke using animal models
Official title: Stroke Preclicinal Assessment Network
Funded at Massachusetts General Hospital · NIH-10991796 · Data updated 2026-11-12
This study is looking at new treatments for stroke using animal models to help make sure they work well before testing them in people, so we can find better ways to help stroke patients recover.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $577,622 |
| NIH project number | 5U01NS130588-03 |
| Project ID | NIH-10991796 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of stroke or those who have experienced a stroke and are seeking innovative treatment options.
✕Less likely to help
Patients with conditions unrelated to stroke or those who are not eligible for clinical trials may not benefit from this research.
What this research studies
This research investigates the effectiveness of potential stroke therapies through a multicenter platform that conducts preclinical studies. By utilizing animal models, the team aims to improve the design and reproducibility of stroke research, addressing past challenges in predicting clinical success. Each animal involved in the study undergoes MRI scans and neurological tests at specific intervals to monitor outcomes. The goal is to refine treatment approaches and enhance the understanding of stroke interventions before they reach human trials.
Why it matters
Potential benefit: If successful, this research could lead to more effective stroke treatments that improve patient outcomes.
How similar studies have gone: Previous research has shown that improving preclinical study designs can lead to better predictive outcomes for clinical trials, indicating a promising approach.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Ayata, Cenk — Massachusetts General Hospital
- Study coordinator: Ayata, Cenk
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.