Assessing mitochondrial function in individuals with Down syndrome using advanced imaging techniques
Imaging of Mitochondial Complex I function in Down Syndrome
This study is looking at how well the energy-producing parts of cells work in people with Down syndrome using a special imaging technique called PET scans, with the goal of finding ways to improve their health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11145941 on NIH RePORTER |
What this research studies
This research aims to evaluate mitochondrial function in individuals with Down syndrome by using a specialized imaging technique called Positron Emission Tomography (PET). The study will utilize a radioligand known as [18F]-BCPP-EF to visualize and measure the activity of Mitochondrial Complex I, which is crucial for energy production in cells. By understanding how mitochondrial function is affected in Down syndrome, researchers hope to identify potential therapeutic targets that could improve health outcomes for these individuals. The study will involve participants undergoing PET scans to assess their mitochondrial activity in real-time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome aged 21 years and older.
Not a fit: Patients without Down syndrome or those under 21 years of age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance mitochondrial function and overall health in individuals with Down syndrome.
How similar studies have performed: Previous studies using similar imaging techniques have shown promising results in assessing mitochondrial function in other neurodegenerative conditions, indicating potential for success in this novel application.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Price, Julie C — Massachusetts General Hospital
- Study coordinator: Price, Julie C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.