Assessing hip fracture risk in patients with HIV and HCV
Official title: MRI Assessment of Hip Fracture Risk and Therapy Response in HIV/HCV Coinfection
Funded at University of Pennsylvania · NIH-10666414 · Data updated 2026-11-12
This study is looking at how having both HIV and hepatitis C affects bone strength and the risk of hip fractures, using special MRI scans to find out more about bone health in these patients compared to those with just hepatitis C and healthy people, all to help improve care for those at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 11, 2019 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $471,124 |
| NIH project number | 5R01AR076392-05 |
| Project ID | NIH-10666414 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are co-infected with HIV and HCV, as well as those infected with HCV alone.
✕Less likely to help
Patients who are not infected with either HIV or HCV may not benefit from this research.
What this research studies
This research investigates the risk of hip fractures in patients who are co-infected with HIV and HCV, as these infections significantly increase fracture risk. Using advanced magnetic resonance imaging (MRI), the study aims to evaluate bone strength and structure in these patients compared to those with only HCV and healthy individuals. The goal is to identify bone deficits that traditional methods may overlook and to explore how antiviral treatments for HCV may influence bone health. By analyzing these factors, the research seeks to improve clinical tools for assessing fracture risk in this vulnerable population.
Why it matters
Potential benefit: If successful, this research could lead to better assessment and management of fracture risk in patients with HIV and HCV, potentially reducing morbidity and mortality associated with hip fractures.
How similar studies have gone: While the approach of using MRI to assess bone health in this specific population is innovative, similar studies have shown promise in using advanced imaging techniques to evaluate bone density and strength.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Rajapakse, Chamith Sudesh — University of Pennsylvania
- Study coordinator: Rajapakse, Chamith Sudesh
Related research
Other NIH-funded projects on the same topics.
-
MAC-STILA: Safer, gentler anesthesia for hip fracture in older adults
A multi-center trial tests a new anesthesia approach (MAC-STILA) to reduce delirium and other problems after hip-fracture surgery in older adults with dementia.
-
HIP ATTACK-2: Faster surgery for hip fracture patients with heart injury
A multicenter trial tests whether operating within 6 hours after hip fracture improves survival and recovery for patients who also have acute heart injury.
-
Hip fracture risk in people with chronic kidney disease
A study focused on why hip fractures happen and how to prevent them in people with chronic kidney disease.
-
How bones weaken in different ways that lead to hip fractures
This project looks at how differences in bone size, mineral content, and bone area relate to hip fracture risk in older men and women.
-
Monitored sedation with local anesthetic injections for older adults with hip fracture
This project compares monitored sedation plus local anesthesia injections to standard general anesthesia for older adults having hip fracture surgery to reduce postoperative delirium.
-
Developing a new treatment to improve muscle recovery after hip fractures in older adults
This study is testing a new pill called RT-002 to see if it can help older adults heal better and regain strength after a hip fracture, with the hope of making their recovery easier and improving their overall quality of life.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.