Assessing hip fracture risk in patients with HIV and HCV
MRI Assessment of Hip Fracture Risk and Therapy Response in HIV/HCV Coinfection
This study is looking at how having both HIV and hepatitis C affects bone strength and the risk of hip fractures, using special MRI scans to find out more about bone health in these patients compared to those with just hepatitis C and healthy people, all to help improve care for those at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10666414 on NIH RePORTER |
What this research studies
This research investigates the risk of hip fractures in patients who are co-infected with HIV and HCV, as these infections significantly increase fracture risk. Using advanced magnetic resonance imaging (MRI), the study aims to evaluate bone strength and structure in these patients compared to those with only HCV and healthy individuals. The goal is to identify bone deficits that traditional methods may overlook and to explore how antiviral treatments for HCV may influence bone health. By analyzing these factors, the research seeks to improve clinical tools for assessing fracture risk in this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are co-infected with HIV and HCV, as well as those infected with HCV alone.
Not a fit: Patients who are not infected with either HIV or HCV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better assessment and management of fracture risk in patients with HIV and HCV, potentially reducing morbidity and mortality associated with hip fractures.
How similar studies have performed: While the approach of using MRI to assess bone health in this specific population is innovative, similar studies have shown promise in using advanced imaging techniques to evaluate bone density and strength.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Rajapakse, Chamith Sudesh — University of Pennsylvania
- Study coordinator: Rajapakse, Chamith Sudesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.