Assessing cancer risk through urine DNA analysis
Urinary DNA Adductomics for the Assessment of Exposure to Cancer Risk Factors
This study is looking at how certain things in our environment and our bodies can harm our DNA, which might lead to health problems like cancer, and it’s for anyone interested in understanding their cancer risk through a simple urine test that checks for DNA damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10544501 on NIH RePORTER |
What this research studies
This research investigates how exposure to environmental and biological agents can damage DNA, potentially leading to diseases like cancer and cardiovascular issues. By utilizing a novel technique called DNA adductomics, the study aims to analyze DNA adducts found in urine, which can provide a non-invasive way to evaluate cancer risk in individuals. This method simplifies the collection and analysis of DNA, making it easier to assess the overall DNA damage in human populations. The findings could help in understanding the relationship between DNA damage and disease risk, ultimately aiding in cancer prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals exposed to environmental toxins or those with a family history of cancer.
Not a fit: Patients who have no exposure to environmental risk factors or those without a history of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, non-invasive method for assessing cancer risk, leading to earlier detection and prevention strategies.
How similar studies have performed: Other research has shown promise in using DNA adductomics for assessing DNA damage, but applying this technique to urine samples is a novel approach.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Cooke, Marcus Stanley — University of South Florida
- Study coordinator: Cooke, Marcus Stanley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.