Assessing blood clot risk in patients with atrial fibrillation using advanced imaging techniques
Patient-specific thrombosis risk in atrial fibrillation by 4D CT imaging of atrial kinetics combined with computational fluid dynamics
This study is looking at how blood flows in the hearts of people with atrial fibrillation to help figure out their risk of developing blood clots, so doctors can make better choices about blood-thinning treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10909947 on NIH RePORTER |
What this research studies
This research focuses on patients with atrial fibrillation (AF), a common heart condition that can lead to blood clots and strokes. By utilizing advanced 4D CT imaging combined with computational fluid dynamics, the study aims to create personalized assessments of thrombosis risk in the left atrial appendage, where clots often form. The researchers will analyze blood flow dynamics and wall motion to better understand how these factors contribute to clot formation. This personalized approach seeks to improve decision-making regarding anticoagulation therapy for AF patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with atrial fibrillation who are at risk for stroke and may require anticoagulation therapy.
Not a fit: Patients who do not have atrial fibrillation or those who are already receiving effective anticoagulation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more tailored anticoagulation treatments, reducing the risk of strokes in AF patients while minimizing unnecessary bleeding complications.
How similar studies have performed: Other research has shown promise in using advanced imaging techniques to assess thrombosis risk, indicating that this approach may lead to significant advancements in patient care.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Kahn, Andrew — University of California, San Diego
- Study coordinator: Kahn, Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.