Aspirin-linked inflammation in nasal polyps and asthma
Eicosanoid Networks in Aspirin Hypersensitivity
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11233264
This project looks at why aspirin can trigger severe sinus and asthma reactions in people with aspirin-exacerbated respiratory disease (AERD).
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11233264 on ClinicalTrials.gov |
What this research studies
The team is studying how a specific lipid called LTC4 activates a receptor (CysLT2R) to drive inflammation through the immune signal IL-33. They are testing a platelet-driven pathway that may amplify responses in the airway and sinuses. Researchers combine experiments in specially bred mice with analyses of tissues and cells from carefully diagnosed people with AERD. Together these approaches aim to confirm the biology across species and point to new ways to block the harmful pathway.
Who could benefit from this research
Good fit: People with aspirin-exacerbated respiratory disease (AERD), chronic rhinosinusitis with nasal polyps (CRSwNP), and asthma who have documented sensitivity to aspirin would be the ideal candidates for related clinical work.
Not a fit: People without aspirin sensitivity or with unrelated forms of asthma or sinus disease are unlikely to benefit from these specific findings.
Why it matters
Potential benefit: If successful, this work could identify new targets for treatments that reduce aspirin-triggered sinus and asthma inflammation and possibly change the course of disease.
How similar studies have performed: Existing drugs target leukotrienes but none are disease-modifying for AERD, and the proposed platelet–IL-33 signaling mechanism represents a novel and not-yet-tested clinical target.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOYCE, JOSHUA A — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: BOYCE, JOSHUA A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.