Asian Bipolar Genetics Network
3/4 Asian Bipolar Genetics Network (A-BIG-NET)
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11145221
This project is collecting genetic and health information from adults of Asian ancestry with and without bipolar disorder to find gene variants linked to bipolar illness.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11145221 on ClinicalTrials.gov |
What this research studies
If you join, researchers will ask about your medical history and environmental exposures, collect a DNA sample, and record detailed symptom information. The team is building a large dataset from people across East and South Asia and partner sites to include 27,500 cases and 16,000 controls. Genetic data will be generated using low-pass whole genome sequencing and combined with clinical and environmental measures to look for risk factors specific to Asian populations. The goal is to create a resource that helps researchers understand why bipolar disorder develops and why it may differ between populations.
Who could benefit from this research
Good fit: Adults (21 years and older) of East or South Asian ancestry with a diagnosis of bipolar disorder, as well as adults without bipolar disorder who can serve as controls, are the intended participants.
Not a fit: People under 21, those not of Asian ancestry, or anyone seeking immediate changes to their treatment are unlikely to receive direct clinical benefits from participation.
Why it matters
Potential benefit: This work could identify genetic markers that improve risk prediction, guide more tailored treatments, and reduce disparities in bipolar disorder care for people of Asian ancestry.
How similar studies have performed: Large genetic studies in primarily European populations have identified dozens of bipolar-linked regions, but applying this large-scale sequencing and deep clinical phenotyping to Asian populations is relatively new and expected to reveal additional, population-specific findings.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZANDI, PETER P. — JOHNS HOPKINS UNIVERSITY
- Study coordinator: ZANDI, PETER P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.