Arrdc4 protein as a regulator of heart glucose use during ischemia
Official title: Arrestin domain-containing protein 4 as a novel regulator of glucose metabolism in the ischemic heart
Funded at City College of New York · NIH-11386990 · Data updated 2026-11-12
Scientists are studying how a protein called Arrdc4 affects how the heart uses sugar when blood flow is limited, with the aim of helping people with heart ischemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | City College of New York NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $392,500 |
| NIH project number | 5R01HL166620-04 |
| Project ID | NIH-11386990 on NIH RePORTER |
Who could benefit from this research
✓Could help
Future patients with ischemic heart disease or heart attack could benefit if Arrdc4-related therapies are developed.
✕Less likely to help
Individuals without ischemic heart disease or without opportunities to participate in related translational studies may not directly benefit.
What this research studies
This project uses a mouse model lacking Arrdc4 to see how its absence changes glucose uptake in heart cells during low oxygen. The researchers will compare heart metabolism and outcomes under hypoxic conditions to understand Arrdc4's role in regulating GLUT1 and glycolysis. Findings could reveal new targets to improve heart energy use and recovery after ischemic injury. All work is aimed at translating basic insights into potential therapies for heart patients.
Why it matters
Potential benefit: If successful, the work could identify Arrdc4 as a new target to boost heart glucose uptake during ischemia and improve recovery after heart injury.
How similar studies have gone: Earlier work on Txnip and Arrdc proteins suggests manipulating arrestin-related pathways can alter heart metabolism, with promising outcomes in models.
Where this research is happening
-
City College of New York
New York, United States Active
Researchers
- Principal investigator: Yoshioka, Jun — City College of New York
- Study coordinator: Yoshioka, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.