ARID4B’s Role in ERα Signaling and Breast Cancer
Official title: Molecular Function and Mechanism of ARID4B in ERalpha Signaling and Breast Cancer
Funded at George Washington University · NIH-11420360 · Data updated 2026-11-12
A scientist is studying how ARID4B helps ERα drive breast cancer and whether targeting this pathway could help patients whose cancers resist standard therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | August 2, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $401,094 |
| NIH project number | 5R01CA266432-05 |
| Project ID | NIH-11420360 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with ERα-positive breast cancer, particularly those whose cancer is advanced or resistant to current endocrine therapies.
✕Less likely to help
Patients with cancers not driven by ERα signaling or those not eligible for future targeted interventions may not benefit.
What this research studies
This research will explore how the ARID4B protein supports ERα-driven gene activity in breast cancer, especially in tumors that no longer respond to current endocrine therapies. Using data from patient tumors and laboratory experiments, the team will examine ARID4B’s location on DNA, its interactions with ERα, and how it influences gene expression and tumor growth. The goal is to uncover new points of intervention that could lead to better treatments for advanced ERα+ breast cancer. Results could guide the development of therapies that overcome resistance and extend patient survival.
Why it matters
Potential benefit: Could identify new targets to improve treatment for ERα+ breast cancer, especially in patients with resistant or advanced disease.
How similar studies have gone: Prior studies have linked ARID4B to ERα function and breast cancer progression, supporting potential for meaningful advances although the exact mechanism remains investigational.
Where this research is happening
-
George Washington University
Washington, United States Active
Researchers
- Principal investigator: Wu, Ray-Chang — George Washington University
- Study coordinator: Wu, Ray-Chang
Related research
Other NIH-funded projects on the same topics.
-
Improving Breast Cancer Guideline Adherence in Nigeria
Aimed at helping doctors in Nigeria follow international guideline-based breast cancer care to improve outcomes for women with breast cancer.
-
Genomic study to understand how genetics and epigenetics shape triple-negative breast cancer in African ancestry
This study looks at how inherited genes and gene activity affect triple-negative breast cancer in people of African ancestry to better understand why outcomes can be worse.
-
Translational breast cancer research to improve treatment options
A comprehensive program at Baylor College of Medicine is focusing on breast cancer; researchers will advance targeted therapies and biomarkers to help patients with aggressive or hard-to-treat forms.
-
Cancer Pain Management for Asian American Breast Cancer Survivors with Depressive Symptoms
A technology-based program helps Asian American breast cancer survivors with depressive symptoms manage chronic pain more effectively from home using a web app and mobile tools.
-
Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans
A study aims to block two cancer-promoting pathways (IL-6 and CDK4/6) to prevent or reduce progression of triple-negative breast cancer in women veterans.
-
Gut bacteria and metabolites linked to breast density and cancer risk
A small, patient-friendly study will explore whether gut bacteria and their byproducts are connected to high breast density, which can raise cancer risk and make screening less accurate.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.