Approach-avoidance training to help veterans recover from alcohol problems

Enhancing treatment outcomes among veterans with alcohol use disorder: Clinical and neural markers of adjunctive approach-avoidance training

['FUNDING_OTHER'] · VA SAN DIEGO HEALTHCARE SYSTEM · NIH-11220689

This project tests a computer program that trains Veterans with alcohol use disorder to reduce automatic approach toward alcohol and support recovery alongside their usual care.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorVA SAN DIEGO HEALTHCARE SYSTEM (nih funded)
Locations1 site (SAN DIEGO, UNITED STATES)
Trial IDNIH-11220689 on ClinicalTrials.gov

What this research studies

If you are a Veteran receiving treatment for alcohol use disorder, researchers will add a computer-delivered approach-avoidance training (AAT) to your usual care to retrain automatic responses to alcohol cues. The program asks you to repeatedly push away images of alcohol and pull neutral images while researchers measure changes in behavior and brain responses linked to approach bias. Participants will complete questionnaires, drinking logs, and brain imaging sessions to track cravings, relapse, and day-to-day functioning. The team will look at whether AAT helps Veterans, including those with common co-occurring problems, regain work, social, and daily activities.

Who could benefit from this research

Good fit: Ideal candidates are Veterans diagnosed with alcohol use disorder who are receiving or willing to receive treatment at the VA and can attend computer sessions and occasional brain scans.

Not a fit: People without alcohol use disorder, non-veterans, or those unable or unwilling to do computer training or attend in-person visits (including imaging) are unlikely to benefit.

Why it matters

Potential benefit: If successful, this could lower relapse risk, reduce cravings, and help Veterans regain work, social, and daily functioning.

How similar studies have performed: Previous trials of approach-avoidance training have shown promise in reducing alcohol approach bias and improving drinking outcomes when added to standard care, but this work applies the approach specifically to Veterans and examines brain markers.

Where this research is happening

SAN DIEGO, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.