APOL1 Gene and Long-Term Kidney Transplant Outcomes
1-13 ApoL1 Genotypes in Kidney Donors and Long-Term Outcomes in Kidney Transplant Recipients Clinical Center
This project looks at how a gene called APOL1 in kidney donors might affect how well transplanted kidneys work over time for patients.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11137838 on NIH RePORTER |
What this research studies
This project is part of a larger network called APOLLO, which is conducting the biggest observational study to date on kidney transplant recipients and donors. We are studying a specific gene called APOL1 in kidney donors to see if certain changes in this gene might be linked to how long a transplanted kidney lasts. Our center has been a leader in enrolling both kidney transplant recipients and living kidney donors from Florida, Puerto Rico, and California. By collecting DNA from these participants, we hope to better understand the factors that influence long-term kidney transplant success. This information could help doctors make more informed decisions and improve outcomes for patients receiving kidney transplants.
Who could benefit from this research
Good fit: Ideal candidates are kidney transplant recipients and living kidney donors who have received or donated a kidney at participating centers in Florida, Puerto Rico, or California.
Not a fit: Patients who have not undergone a kidney transplant or donated a kidney would not directly benefit from participating in this specific observational study.
Why it matters
Potential benefit: If successful, this work could help doctors better predict the long-term success of kidney transplants and personalize care for patients based on donor genetics.
How similar studies have performed: This project is part of the largest observational study of its kind, building upon existing knowledge about APOL1 and kidney transplantation.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Fornoni, Alessia — University of Miami School of Medicine
- Study coordinator: Fornoni, Alessia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.