APOL1 and long-term kidney transplant outcomes
5/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
This project follows Black and Hispanic living kidney donors and transplant recipients to learn how APOL1 gene differences affect transplant health over time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11137653 on NIH RePORTER |
What this research studies
You would join a group of donors and transplant recipients followed across 11 transplant centers in the Northeastern U.S. Doctors will collect detailed medical records and biospecimens, including blood, urine, urine albumin-to-creatinine ratio, and biopsy slides. The team will link those clinical data to APOL1 gene results and look for additional “second hits” that might lead to transplant problems. If you wish, the study can return your APOL1 genotype results to you.
Who could benefit from this research
Good fit: Ideal candidates are Black or African American adults, including Black Hispanic living kidney donors and people who have received kidney transplants, who can provide health information and biospecimen samples.
Not a fit: People without African ancestry, those not involved in kidney donation or transplantation, or those unwilling to provide samples may not see direct benefits.
Why it matters
Potential benefit: If successful, this work could help identify donors or recipients at higher risk for transplant problems so care can be personalized.
How similar studies have performed: Prior research has linked APOL1 risk variants to kidney disease, but large long-term transplant-focused data are still limited, making this effort relatively novel and important.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Mohan, Sumit — Columbia University Health Sciences
- Study coordinator: Mohan, Sumit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.