ApoE and blood vessel health in Alzheimer’s risk and VCID
Official title: Effect of apoE genotype on eNOS regulation and the development of VCID
Funded at Roskamp Institute, INC. · NIH-11340643 · Data updated 2026-11-12
This NIH grant explores how a genetic factor called apoE e4 affects blood vessel function in the brain and its link to vascular cognitive impairment and Alzheimer’s disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roskamp Institute, INC. NIH-funded |
| Lab location | 1 site (Sarasota, United States) |
| Project start | September 1, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $599,804 |
| NIH project number | 1R01NS148580-01 |
| Project ID | NIH-11340643 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with or at risk for Alzheimer’s disease or vascular cognitive impairment, particularly those with APOE e4 genotype.
✕Less likely to help
People without APOE e4 or those without vascular contributions to cognitive impairment may see limited direct benefit.
What this research studies
Researchers will study how apoE genotype changes the regulation of eNOS, the enzyme that keeps brain blood vessels healthy. They will use animal models and human-derived samples to understand how apoE4 may worsen blood flow, barrier integrity, and brain pathology tied to Alzheimer’s disease. The work aims to map the molecular steps from apoE4 to vascular problems and cognitive changes, with a focus on the brain’s blood vessels. If the mechanisms are clarified, this could point to new ways to protect brain vessels and slow cognitive decline in at-risk people.
Why it matters
Potential benefit: A clearer path to targeted therapies that protect brain blood vessels and may slow dementia progression in people with apoE4.
How similar studies have gone: Previous work links apoE4 to vascular dysfunction and dementia; this project builds on that foundation with a focused genetic mechanism.
Where this research is happening
-
Roskamp Institute, INC.
Sarasota, United States Active
Researchers
- Principal investigator: Eisenbaum, Maxwell — Roskamp Institute, INC.
- Study coordinator: Eisenbaum, Maxwell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.