Antibody protection for dengue, Zika and related viruses
ANTIBODY-BASED PROTECTION AGAINST FLAVIVIRUSES
['FUNDING_U01'] · WASHINGTON UNIVERSITY · NIH-11285193
Researchers are developing and using antibodies to block dengue, Zika, and similar viruses to help people at risk of serious infection.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11285193 on ClinicalTrials.gov |
What this research studies
If I'm exposed to dengue, Zika, or related tick-borne viruses, this project studies how antibodies in my blood can stop the virus. The team is mapping virus shapes and testing which antibodies can neutralize different viral forms that hide or expose key parts. They will hunt for new powerful antibodies that recognize complex viral surfaces and could be turned into treatments or guide better vaccines. Most of the work is done in the lab using structural studies and antibody testing against multiple virus types.
Who could benefit from this research
Good fit: People who have had dengue, Zika, or other flavivirus infections or who live in or travel to areas where these viruses circulate may be eligible to provide blood samples or join related clinical studies.
Not a fit: People without any exposure risk to flaviviruses or those needing immediate clinical treatment for an acute severe infection are unlikely to receive direct benefit from this lab-focused grant.
Why it matters
Potential benefit: If successful, this work could lead to new antibody therapies or improved vaccines that prevent severe dengue, Zika, and related infections.
How similar studies have performed: Previous research has found some neutralizing antibodies and produced promising vaccine and therapeutic leads, but broadly protective antibodies across dengue serotypes and tick-borne flaviviruses remain limited.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIAMOND, MICHAEL S — WASHINGTON UNIVERSITY
- Study coordinator: DIAMOND, MICHAEL S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.