Antibody dynamics to improve Chagas disease diagnostics and prognosis
Official title: High-throughput analysis of dynamics of antibody responses against defined epitopes: prioritization of diagnostic and prognostic markers for Chagas disease
Funded at Institute/research/biotechnology Fdn · NIH-11412724 · Data updated 2026-11-12
A researcher in Argentina is studying how antibody responses to defined parts of the parasite change over time to identify better diagnostic and prognosis markers for Chagas disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute/research/biotechnology Fdn NIH-funded |
| Lab location | 1 site (San Martin, Argentina) |
| Project start | September 9, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $133,308 |
| NIH project number | 5R01AI183396-02 |
| Project ID | NIH-11412724 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults and children with Chagas disease who are under follow-up and undergoing treatment or monitoring.
✕Less likely to help
Patients not enrolled in follow-up care or not affected by Chagas disease would not directly benefit.
What this research studies
This project analyzes how the body’s antibodies against specific parasite pieces evolve during infection and treatment. It uses high-throughput methods to map antibody responses and identify markers that predict cure or relapse. The findings could lead to faster, more reliable ways to monitor treatment success for people with Chagas disease. The work focuses on patients in the Americas and will integrate clinical follow-up data with lab analyses.
Why it matters
Potential benefit: If successful, the study could yield earlier and more accurate tests to monitor treatment response in Chagas patients.
How similar studies have gone: Previous work has used antibody trends for treatment endpoints, but this project seeks earlier informative outcomes with high-throughput profiling.
Where this research is happening
-
Institute/research/biotechnology Fdn
San Martin, Argentina Active
Researchers
- Principal investigator: Aguero, Fernan Gonzalo — Institute/research/biotechnology Fdn
- Study coordinator: Aguero, Fernan Gonzalo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.