Antibodies and lab tools for Ebola and Marburg viruses
Antibody and Reagent Development Core
This project creates standardized antibodies, cell lines, and mouse models to help scientists study and counteract Ebola and Marburg infections.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11090522 on NIH RePORTER |
What this research studies
This core makes and distributes lab reagents such as mouse monoclonal and synthetic antibodies targeted to Ebola and Marburg proteins. It also produces knockout cell lines and conditional knockout mouse models of host factors linked to how these viruses replicate. The core works with the program's research projects to prioritize and validate reagents so experiments across the program use the same standardized materials. By sharing these tools with collaborating labs, the work speeds up and strengthens studies of viral–host interactions that underlie severe disease.
Who could benefit from this research
Good fit: This core does not enroll patients, but people affected by Ebola or Marburg could be future participants in related research projects that use these reagents or could donate samples to those studies.
Not a fit: Patients with conditions unrelated to filoviruses are unlikely to see any direct benefit from this core's work.
Why it matters
Potential benefit: If successful, these reagents could speed development of better diagnostics, antivirals, and vaccines for filoviral infections.
How similar studies have performed: Making monoclonal antibodies and using knockout cell and mouse models is a well-established approach that has supported prior advances in Ebola research and therapy development.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Leung, Daisy W — Washington University
- Study coordinator: Leung, Daisy W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.