Antibiotic resistance after giving azithromycin to children in Niger
Résistance Evaluée contre la Vie des Enfants au Niger-Implementation et Recherche (REVENIR). Community antimicrobial resistance after azithromycin distribution: selection, spillover, co-selection
This project checks if giving azithromycin to young children in Niger increases antibiotic resistance in those children and in their communities.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11222692 on NIH RePORTER |
What this research studies
If you join, researchers will follow communities in Niger where azithromycin is given to young children and collect samples over time from children and nearby household members. They will compare areas that received different distribution strategies and track resistance in bacteria to azithromycin and other common antibiotics. The team will look for signs that resistance spreads from treated children to untreated people and whether resistance keeps rising or levels off over years. The work combines community visits, sample collection, and laboratory testing to measure changes in antibiotic resistance.
Who could benefit from this research
Good fit: Young children under five years old in participating Niger communities and their household members are the people most likely to be included.
Not a fit: People who do not live in the study communities or who are not connected to treated children are unlikely to get direct benefits from participating.
Why it matters
Potential benefit: Findings could help programs use azithromycin in ways that save children's lives while limiting the rise and spread of antibiotic resistance.
How similar studies have performed: Previous mass azithromycin programs have shown reductions in child deaths but have often produced increased antibiotic resistance, so this work builds on known results while focusing on long-term, community-level and co-selection effects.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: O'brien, Kieran — University of California, San Francisco
- Study coordinator: O'brien, Kieran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.