Annual systems biology meeting on respiratory infections
Administrative Supplement Request for 2025 Systems Biology for Infectious Diseases Annual Meeting
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11300082
This program uses human lung cells, patient samples, and computer models to find host factors that could lead to better treatments and predict who gets sicker from respiratory infections like TB, COVID-19, flu, and RSV.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11300082 on ClinicalTrials.gov |
What this research studies
From a patient perspective, scientists will collect and analyze human lung samples and blood from people with respiratory infections and grow three-dimensional airway organoids to mimic the human airway. They will measure proteins, genes, and structures in those samples using proteomics, genetics, and structural biology techniques. The team will combine these new data with existing datasets and use network and structural computer modeling to pinpoint host proteins, complexes, and pathways that control infection and disease severity. Work focuses on tuberculosis and several respiratory viruses (including SARS‑CoV‑2 variants, influenza, and RSV) to generate clinically relevant insights.
Who could benefit from this research
Good fit: Ideal participants are people with current or recent respiratory infections (for example TB, COVID‑19, influenza, or RSV) who are willing to provide blood and respiratory samples for research.
Not a fit: People without respiratory infections or those who need immediate clinical treatment may not get direct benefit from participating in this research-focused effort.
Why it matters
Potential benefit: If successful, this work could reveal new drug targets and biomarkers to guide treatments and predict which patients are at higher risk of severe disease.
How similar studies have performed: Similar systems-biology and proteomics programs, including earlier Host-Pathogen Map Initiative work, have produced useful biological leads but remain largely exploratory for developing new therapies.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KROGAN, NEVAN J — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: KROGAN, NEVAN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway infections