Animal models for testing HIV vaccine ideas
Scientific Core: Animal Models
This project builds and uses special mice with human immune parts to speed development of better HIV vaccines for people at risk of HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11312609 on NIH RePORTER |
What this research studies
Researchers will make and use humanized mice that carry real human antibody genes to try out different vaccine designs and prime‑and‑boost strategies. The Animal Model Core will create up to six new knock‑in mouse lines based on insights from human B cells and will run immunizations using existing HIV models. Tissues and samples from these mice will be shared with other teams in the consortium for detailed immune analysis. The goal is to guide which vaccine candidates move forward into early human testing.
Who could benefit from this research
Good fit: People living with or at high risk for HIV are the intended beneficiaries and could become candidates for future vaccine trials informed by this work.
Not a fit: Patients seeking immediate treatment benefits or people without HIV-related concerns are unlikely to gain direct clinical benefit from this animal-model focused project.
Why it matters
Potential benefit: If successful, this work could speed the selection of vaccine candidates that trigger strong human antibody responses and ultimately help prevent HIV infections.
How similar studies have performed: Humanized mouse models and germline‑targeting or epitope‑focused vaccine approaches have already helped several candidates reach early human trials, so this builds on promising but still early successes.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Batista, Facundo Damian — Scripps Research Institute, the
- Study coordinator: Batista, Facundo Damian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.