Animal Model & Clinical Core for congenital heart disease research
Official title: Animal Model & Clinical Core
Funded at Florida International University · NIH-11401958 · Data updated 2026-11-12
A research program provides well-defined sheep models of congenital heart disease and a centralized database with patient samples and clinical data to support studies that may benefit people with CHD.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project start | August 10, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $371,205 |
| NIH project number | 5P01HL146369-08 |
| Project ID | NIH-11401958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are researchers studying congenital heart disease who need access to animal models, patient-derived samples, and comprehensive hemodynamic data to advance translational work.
✕Less likely to help
Patients without CHD or without access to translational research resources may not directly benefit from this core.
What this research studies
Core C creates reproducible ovine models of congenital heart disease using fetal surgery and offers a full suite of animal-related experiments, tissues, and expertise. It already has a secure biobank with peri-operative samples and clinical data from over 500 patients. Researchers can access ovine CHD models, tissues, and primary cells, plus data analyses that cover invasive and non-invasive heart–lung measurements, imaging, and pulmonary vascular assessments. This core aims to accelerate translational work by supplying both biological materials and advanced analytical capabilities. The work is centered on congenital heart disease and the associated experimental and clinical resources.
Why it matters
Potential benefit: If successful, patients with CHD could benefit from faster development of therapies and better understanding of disease mechanisms through shared resources and models.
How similar studies have gone: Previous work using ovine CHD models and biobanked clinical data has supported translational insights and informed preclinical studies.
Where this research is happening
-
Florida International University
Miami, United States Active
Researchers
- Principal investigator: Fineman, Jeffrey R — Florida International University
- Study coordinator: Fineman, Jeffrey R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.