Angiotensin-(1-7) for obesity-related high blood pressure
Official title: Angiotensin-(1-7) and Cardiovascular Derangements in Obesity Hypertension
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-11309599 · Data updated 2026-11-12
This work looks at whether a natural hormone called angiotensin-(1-7) can lower blood pressure and improve blood vessel and metabolic health in people with obesity-linked hypertension.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | April 15, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $706,467 |
| NIH project number | 5R01HL170140-03 |
| Project ID | NIH-11309599 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with obesity who have high blood pressure related to their weight and who meet the study's medical criteria would be the most likely candidates.
✕Less likely to help
People whose hypertension is not linked to obesity, pregnant individuals, or those with certain serious medical conditions may not be eligible or likely to benefit.
What this research studies
From my point of view as a patient, researchers are studying a natural hormone that may help the high blood pressure that often comes with obesity. They will use results from animal studies and also give short, controlled hormone infusions to people while taking blood tests, blood pressure readings, and noninvasive measures of blood vessel and nerve function. The team will compare measures before and after treatment to see if blood pressure, endothelial function, and insulin sensitivity improve. Study visits could include IV infusions and follow-up monitoring at the medical center.
Why it matters
Potential benefit: If successful, this could offer a new treatment that lowers blood pressure in people with obesity while also improving blood vessel health and insulin sensitivity.
How similar studies have gone: Animal studies and limited early human infusion data have shown promising reductions in blood pressure and improved metabolic signs, but larger clinical benefits remain unproven.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Arnold, Amy Christine — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Arnold, Amy Christine
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.