Angiogenin to Help Restore Blood Formation After Radiation
Official title: Development of angiogenin as a novel radiation medical countermeasure for acute radiation syndrome
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-11406062 · Data updated 2026-11-12
A study to test whether angiogenin can protect and rebuild the blood-forming system after radiation exposure, with potential to help people who survive acute radiation syndrome.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | September 4, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $561,444 |
| NIH project number | 5U01AI187053-02 |
| Project ID | NIH-11406062 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with or at risk of hematopoietic acute radiation syndrome or individuals exposed to radiation who could benefit from marrow-supporting therapies in the future.
✕Less likely to help
Patients without radiation exposure or hematopoietic illness may not benefit from this approach.
What this research studies
This project explores using angiogenin, a small protein, to help bone marrow recover after radiation damage. It will test how ANG keeps blood stem cells healthy while promoting quick growth of myeloid progenitors to restore blood counts. The work will be done in mouse models to understand timing, dosing, and mechanisms before considering human studies. If ANG proves effective, it could lead to a treatment that reduces infections, bleeding, and the need for supportive care after radiation exposure.
Why it matters
Potential benefit: If successful, ANG could become a treatment to speed up recovery from radiation-induced bone marrow damage and improve survival.
How similar studies have gone: Previous work in animals suggests ANG can support hematopoietic recovery, but human data are not yet established.
Where this research is happening
-
Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Singh, Vijay K — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Singh, Vijay K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.