Androgens and peanut allergy differences in people of all ages
Official title: Androgens protect against development of immune responses to peanut
Funded at University of Nebraska Kearney · NIH-11199120 · Data updated 2026-11-12
A small NIH grant explores how male hormones might influence peanut allergy development and why girls and women show more peanut allergies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Kearney NIH-funded |
| Lab location | 1 site (Kearney, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $127,159 |
| NIH project number | 1R16AI192268-01 |
| Project ID | NIH-11199120 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with peanut allergy risk factors or a history of peanut exposure and sex-related considerations (both males and females across age groups).
✕Less likely to help
Very young children or individuals without peanut exposure history may not directly benefit from these findings.
What this research studies
This grant looks at why sex differences appear in peanut allergy and whether androgens (male hormones) affect immune responses to peanut. Researchers will use existing data and laboratory studies to map how exposure to peanut through non-oral routes could drive allergy, and how sex hormones might change that process. The study aims to uncover immune pathways that could lead to new ways to prevent peanut allergy in children and adults. The work could inform future trials or prevention strategies that consider sex and hormonal status.
Why it matters
Potential benefit: If successful, the findings could guide personalized prevention or treatment approaches for peanut allergy based on sex and hormone influences.
How similar studies have gone: Previous animal studies show that non-oral peanut exposure can promote allergy and that sex differences exist, but human relevance remains to be confirmed.
Where this research is happening
-
University of Nebraska Kearney
Kearney, United States Active
Researchers
- Principal investigator: Dolence, Joseph J — University of Nebraska Kearney
- Study coordinator: Dolence, Joseph J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.