Androgen Signals in the Brain and Behavior Differences Between Sexes
Sex-specific role of androgen signaling in neuroendocrine-behavior interface
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11093519
This research explores how androgen hormones affect brain function and behavior differently in men and women, especially when these hormones are out of balance.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11093519 on ClinicalTrials.gov |
What this research studies
Many people experience health issues when their androgen hormone levels are too high or too low, leading to problems like reproductive difficulties, changes in sexual desire, fatigue, depression, or bone loss. This project aims to understand how these androgen hormones directly influence specific areas of the brain that control behavior. We want to uncover the exact brain circuits and cell types involved in these sex-specific responses to androgen imbalances. This knowledge is especially important for individuals with conditions like gender dysphoria who receive hormone treatments, as well as for understanding the effects of androgen abuse.
Who could benefit from this research
Good fit: This research is relevant for individuals experiencing health issues related to androgen hormone imbalances, such as reproductive dysfunction, changes in sexual behavior, fatigue, depression, or bone loss.
Not a fit: Patients whose health concerns are not related to androgen hormone levels or brain function would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better treatments and interventions for conditions caused by androgen imbalances, improving reproductive health, mood, and overall well-being for both men and women.
How similar studies have performed: Previous studies using genetic models in mice have replicated some male reproductive dysfunctions linked to low androgens, but the specific brain circuits and mechanisms are largely unknown.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ELIAS, CAROL FUZETI — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: ELIAS, CAROL FUZETI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.