Ancestry-linked genetic factors in Hispanic/Latino cardiometabolic health
Multi-omics study of ancestry enriched associations in Hispanics/Latinos
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11143941
Using genetic and molecular data to find ancestry-linked factors that affect heart and metabolic health in Hispanic/Latino people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11143941 on ClinicalTrials.gov |
What this research studies
If you join, researchers will analyze DNA and other biological data from large groups of Hispanic/Latino adults to find genomic regions inherited from different ancestral groups that relate to cardiometabolic disease. They will integrate genomics with multi-omics data (such as gene expression and other molecular measures) to narrow down which variants might drive risk. The team will then check these findings for clinical relevance using participants from the All of Us program. This work aims to explain ancestry-related differences in disease risk and inform better prevention and care.
Who could benefit from this research
Good fit: Adults who identify as Hispanic or Latino, particularly those with or at risk for cardiometabolic conditions and willing to provide genetic or related biological data, are the ideal candidates.
Not a fit: People who are not of Hispanic/Latino ancestry or those looking for immediate clinical treatments rather than contributing research data are unlikely to directly benefit.
Why it matters
Potential benefit: Could enable ancestry-informed risk prediction and more tailored prevention or treatment strategies for Hispanic/Latino patients with cardiometabolic disease.
How similar studies have performed: Previous genome-wide studies have found ancestry-linked risk variants, but combining multi-omics and validating results specifically in Hispanic/Latino populations is a newer approach with limited prior validation.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRANCESCHINI, NORA — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: FRANCESCHINI, NORA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiometabolic Disease