Analyzing visual field changes in glaucoma patients
Resubmission: Latent Class Trajectory Analysis in the OHTS Study
This study looks at how people with ocular hypertension notice changes in their vision over time, so we can better understand who might need more treatment and who might not, helping to create personalized care plans for everyone.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10675764 on NIH RePORTER |
What this research studies
This research investigates how different patients with ocular hypertension experience changes in their visual fields over time. By using a method called latent class mixed model (LCMM), the study aims to classify patients based on their rates of progression towards primary open-angle glaucoma (POAG). This approach allows for a more personalized understanding of visual loss, helping to identify those at risk of rapid deterioration and those who may not need aggressive treatment. The goal is to improve patient outcomes by tailoring treatment strategies based on individual trajectories of visual field change.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ocular hypertension who are at risk of developing primary open-angle glaucoma.
Not a fit: Patients who do not have ocular hypertension or those who have already been diagnosed with advanced glaucoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment plans for patients at risk of glaucoma, potentially preserving their vision.
How similar studies have performed: Previous studies using similar latent class modeling approaches have shown promise in understanding disease progression, suggesting that this method could be effective in this context as well.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Liu, Lei — Washington University
- Study coordinator: Liu, Lei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.