Analyzing uterine and cervical samples to detect ovarian cancer early
Genome-wide methylation and proteomic analysis of uterine lavage and cervical swab for early detection of ovarian cancer
This study is looking at how to use samples from the uterus and cervix to find early signs of ovarian cancer, helping women get diagnosed sooner and more easily through regular check-ups.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10674873 on NIH RePORTER |
What this research studies
This research investigates the use of uterine lavage and cervical swab samples to identify early signs of ovarian cancer. By employing advanced genome-wide methylation and proteomic analysis techniques, the study aims to find biological signals that indicate the presence of ovarian cancer at an earlier stage than current methods allow. The approach focuses on optimizing a combined test that can detect these signals in samples collected from women, potentially leading to more effective early detection strategies. Patients may provide samples through routine gynecological procedures, making participation accessible.
Who could benefit from this research
Good fit: Ideal candidates for this research are postmenopausal women who are at normal risk for ovarian cancer and are undergoing routine gynecological examinations.
Not a fit: Patients who are not postmenopausal or those with a high risk of ovarian cancer due to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more reliable method for early detection of ovarian cancer, improving treatment outcomes.
How similar studies have performed: Previous research has shown promise in using alternative biospecimens for cancer detection, but this specific approach is novel and untested.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Skates, Steven J — Massachusetts General Hospital
- Study coordinator: Skates, Steven J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.