Analyzing the tumor environment in multiple myeloma to improve immunotherapy and drug testing.
Microphysiological platform for analyzing multiple myeloma's tumor microenvironment, enabling immunotherapy assessment and drug screening.
This study is looking at how the environment around myeloma cells affects the cancer and its response to treatments, using a special 3D model to better understand why some patients do well with therapies like CAR-T while others don’t.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10916687 on NIH RePORTER |
What this research studies
This research focuses on understanding how the tumor microenvironment (TME) affects multiple myeloma, a type of blood cancer. By creating a 3D cell culture system that closely mimics the TME, researchers aim to study how different components influence cancer cell behavior and treatment resistance. The project will utilize advanced tissue engineering techniques to replicate the conditions found in actual tumors, including factors like oxygen levels and immune interactions. This approach will help identify why some patients respond to therapies like CAR-T while others do not.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with multiple myeloma, particularly those who have experienced relapse or resistance to current therapies.
Not a fit: Patients with other types of cancers or those who are not diagnosed with multiple myeloma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies and personalized treatment strategies for patients with multiple myeloma.
How similar studies have performed: Previous research has shown promise in using 3D culture systems to study cancer biology, indicating that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Northeastern University — Boston, United States (Active)
Researchers
- Principal investigator: Konry, Tania Tali — Northeastern University
- Study coordinator: Konry, Tania Tali
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.