Analyzing the surfaces of orthopedic implants to understand failures
Proteomic Analysis of Implant Surfaces in Athroplasty Failure
This study is looking at old orthopedic implants to find out how infections and immune reactions might cause them to fail, which could help doctors better diagnose and treat patients with these implants in the future.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10765693 on NIH RePORTER |
What this research studies
This research investigates the surfaces of removed orthopedic implants to identify microbial infections and immune responses that contribute to implant failure. Using a technique called sonication, the study collects fluids that contain biofilms from the implant surfaces, which are then analyzed for proteins and other markers. This approach aims to provide a more detailed understanding of both infectious and non-infectious causes of implant failure, potentially leading to improved diagnostic methods and treatment strategies for patients with orthopedic implants.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who have undergone orthopedic surgeries involving implants and are experiencing complications or failures.
Not a fit: Patients who have not had orthopedic implants or those without complications related to their implants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and management of infections and failures related to orthopedic implants, improving patient outcomes.
How similar studies have performed: Similar research approaches have shown promise in improving diagnostic techniques for infections and implant failures, suggesting that this study could build on existing knowledge.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Patel, Robin — Mayo Clinic Rochester
- Study coordinator: Patel, Robin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.