Analyzing the surfaces of orthopedic implants to understand failures
Official title: Proteomic Analysis of Implant Surfaces in Athroplasty Failure
Funded at Mayo Clinic Rochester · NIH-10765693 · Data updated 2026-11-12
This study is looking at old orthopedic implants to find out how infections and immune reactions might cause them to fail, which could help doctors better diagnose and treat patients with these implants in the future.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 18, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $198,750 |
| NIH project number | 5R21AI175039-02 |
| Project ID | NIH-10765693 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients who have undergone orthopedic surgeries involving implants and are experiencing complications or failures.
✕Less likely to help
Patients who have not had orthopedic implants or those without complications related to their implants may not benefit from this research.
What this research studies
This research investigates the surfaces of removed orthopedic implants to identify microbial infections and immune responses that contribute to implant failure. Using a technique called sonication, the study collects fluids that contain biofilms from the implant surfaces, which are then analyzed for proteins and other markers. This approach aims to provide a more detailed understanding of both infectious and non-infectious causes of implant failure, potentially leading to improved diagnostic methods and treatment strategies for patients with orthopedic implants.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and management of infections and failures related to orthopedic implants, improving patient outcomes.
How similar studies have gone: Similar research approaches have shown promise in improving diagnostic techniques for infections and implant failures, suggesting that this study could build on existing knowledge.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Patel, Robin — Mayo Clinic Rochester
- Study coordinator: Patel, Robin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.