Analyzing the role of tyrosine O-sulfation in proteins
Enabling Mass Spectrometry Analysis of the Sulfoproteome
This study is looking at how a special change to proteins in the body, called tyrosine O-sulfation, affects things like viral infections and inflammation, which could help us find new treatments for conditions like AIDS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project ID | NIH-11135992 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific chemical modification, known as tyrosine O-sulfation, affects proteins in the body. By using advanced mass spectrometry techniques, the researchers aim to analyze how this modification influences various biological processes, including viral replication and inflammation. The study will explore the mechanisms behind protein modifications and their implications for health and disease, particularly in conditions like AIDS. Patients may benefit from insights gained into how these processes work, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions related to protein modifications, such as those with viral infections or inflammatory diseases.
Not a fit: Patients who do not have conditions related to protein modifications or who are not affected by viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for diseases related to protein modifications, including viral infections.
How similar studies have performed: Other research has shown success in using mass spectrometry to analyze protein modifications, indicating that this approach is promising and has potential for significant findings.
Where this research is happening
Tallahassee, United States
- Florida State University — Tallahassee, United States (Active)
Researchers
- Principal investigator: Hakansson, Kristina — Florida State University
- Study coordinator: Hakansson, Kristina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.