Analyzing the epigenome using advanced nanopore sequencing techniques
Experimental and bioinformatics platform for epigenome analysis using nanopore sequencing
This study is looking at how tiny changes in our DNA can affect our health, especially during early development, and it uses a new method to get a closer look at these changes, which could help us understand diseases better and improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10934587 on NIH RePORTER |
What this research studies
This research focuses on understanding the epigenetic status of genomes, which includes studying how DNA is modified and how these modifications affect biological processes like gene expression and DNA repair. By utilizing a new technique called nanopore sequencing, researchers aim to gather detailed information about nucleosome occupancy, chromatin accessibility, and DNA methylation. The study will develop experimental protocols and bioinformatics methods to explore these epigenetic events, particularly during early embryonic development and primordial germ cell development. Patients may benefit from insights gained about how epigenetic changes influence health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the genetic and epigenetic factors influencing early development and related health conditions.
Not a fit: Patients with conditions unrelated to epigenetic changes or those not involved in early developmental processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding how epigenetic modifications affect various diseases and developmental processes.
How similar studies have performed: Previous research using nanopore sequencing has shown promise in providing new insights into genomic analysis, suggesting that this approach could be effective.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Au, Kin Fai — University of Michigan at Ann Arbor
- Study coordinator: Au, Kin Fai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.