Analyzing the effects of osteoporosis treatments on bone cells
Official title: Bioinformatics Core
Funded at Massachusetts General Hospital · NIH-11085955 · Data updated 2026-11-12
This study is looking at how a treatment for osteoporosis called romosozumab affects certain bone cells, and it's designed for people with osteoporosis who want to know more about how their treatment works and how it can help improve their bone health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $400,355 |
| NIH project number | 5P50AR080596-03 |
| Project ID | NIH-11085955 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing osteoporosis or related bone health issues.
✕Less likely to help
Patients who do not have osteoporosis or related conditions may not benefit from this research.
What this research studies
This research focuses on understanding how specific osteoporosis treatments, particularly romosozumab, affect bone cells known as osteoblast progenitors and osteocytes. By utilizing advanced bioinformatics techniques, the project will analyze data from both clinical and pre-clinical studies, including single cell RNA sequencing and whole genome sequencing. The Bioinformatics Core will provide essential support in statistical design and data management, ensuring that researchers can effectively interpret complex biological data. This collaborative effort aims to enhance our understanding of bone health and the effectiveness of anabolic therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved osteoporosis treatments that enhance bone health and reduce fracture risk.
How similar studies have gone: Previous research has shown promising results using bioinformatics approaches to analyze treatment effects in osteoporosis, indicating potential for success in this area.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Hsu, Yi-Hsiang — Massachusetts General Hospital
- Study coordinator: Hsu, Yi-Hsiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.