Analyzing the effects of fentanyl and naloxone on non-fatal opioid overdoses
Sentanyl II: A Multi-State Analysis of Fentanyl/Analogs, Naloxone, and Clinical Features of Non-Fatal Opioid Overdose
This study is looking at how fentanyl affects the treatment of people who have had an opioid overdose, focusing on how much naloxone is needed to help them recover, so we can improve care for patients in emergency rooms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10657719 on NIH RePORTER |
What this research studies
This research investigates how fentanyl and its analogs impact the treatment of non-fatal opioid overdose patients in emergency settings. It aims to understand the effectiveness of naloxone, a medication used to reverse opioid overdoses, especially when higher doses are administered due to concerns about fentanyl's potency. By observing 905 adult patients across multiple states, the study will gather data on naloxone dosing needs and the influence of other substances on patient care. The findings will help develop evidence-based guidelines to improve clinical practices for treating opioid overdoses.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced a non-fatal opioid overdose.
Not a fit: Patients who have not experienced an opioid overdose or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for non-fatal opioid overdoses, enhancing patient outcomes and safety.
How similar studies have performed: Previous research has indicated the need for updated naloxone dosing guidelines, suggesting that this approach could yield significant insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Merchant, Roland C — Icahn School of Medicine at Mount Sinai
- Study coordinator: Merchant, Roland C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.