Analyzing the composition of modified oligonucleotide drugs
Multidimensional analytical and computational approach to determine diastereomer compositions in oligonucleotide drug products
This study is exploring new types of medicines called synthetic oligonucleotides to make them safer and more effective for treating diseases by understanding how different chemical changes affect them.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10701023 on NIH RePORTER |
What this research studies
This research focuses on synthetic oligonucleotides, which are a new class of drugs designed to treat various diseases. The project aims to develop advanced analytical methods to understand the different forms these drugs can take due to chemical modifications. By examining how these modifications affect the drugs' properties, the research seeks to improve their effectiveness and safety for patients. The approach involves sophisticated computational techniques to analyze the complex structures of these drugs.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with conditions that may benefit from oligonucleotide therapies, particularly those who have not responded to traditional treatments.
Not a fit: Patients who do not have conditions treatable by oligonucleotide therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer oligonucleotide therapies for patients with various diseases.
How similar studies have performed: Previous research has shown promise in the development of oligonucleotide therapies, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Jones, Jace W — University of Maryland Baltimore
- Study coordinator: Jones, Jace W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.