Analyzing retinal imaging data from premature infants and healthy term infants
Official title: Secondary Data Analysis for Neonates with Retinal OCT Imaging
Funded at Duke University · NIH-10707461 · Data updated 2026-11-12
This study looks at data from 330 babies, some at risk for Retinopathy of Prematurity (ROP) and some healthy, to learn more about their eye health using special imaging technology, with the hope of improving care for infants with ROP.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 30, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $201,860 |
| NIH project number | 5R21EY034138-02 |
| Project ID | NIH-10707461 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include premature infants who have been evaluated for ROP and healthy term infants used as a comparison group.
✕Less likely to help
Patients who are older than 21 years or those who do not have a history of ROP or were not part of the original studies may not benefit from this research.
What this research studies
This research involves analyzing existing data from 330 infants, including those at risk for Retinopathy of Prematurity (ROP) and healthy term infants, who were previously enrolled in studies using advanced imaging technology called Optical Coherence Tomography (OCT). The goal is to better understand the retinal health of these infants by comparing the two groups and identifying potential indicators of eye health or disease. By utilizing data collected from bedside imaging, the research aims to enhance diagnostic methods and improve care for infants with ROP.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic techniques and treatment strategies for infants at risk of vision impairment due to ROP.
How similar studies have gone: Previous studies using OCT imaging in similar populations have shown promising results, indicating that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Toth, Cynthia Ann — Duke University
- Study coordinator: Toth, Cynthia Ann
Related research
Other NIH-funded projects on the same topics.
-
Investigating genetic factors in Lewy body diseases
This study is looking at how changes in a specific gene might play a role in conditions like Parkinson's disease and dementia, so that people can better understand how their genetics affect their health and possibly find more tailored treatments.
-
Targeting the PAX3-FOXO1 protein in a deadly childhood cancer
This study is looking at a specific protein that helps a tough childhood cancer called alveolar rhabdomyosarcoma, with the goal of finding new ways to treat kids who have this illness.
-
Improving population health by studying reproduction and development
This study is looking at how different things in our environment can impact pregnancy and the health of babies, and it’s for people who are planning to have children or are already parents, as it aims to help improve understanding and outcomes for everyone involved.
-
Modeling axon degeneration in C. elegans to help ALS patients
Researchers are using a tiny worm model to uncover how axons break down, which could point to new ways to help people with ALS and related nerve diseases.
-
Induced Suppression of Platelet Activity in Aneurysmal SAH Management
A new approach tests whether carefully reducing platelet activity can improve outcomes after aneurysmal subarachnoid hemorrhage.
-
AI-enhanced virtual reality tool to support remote emergency brain surgery training in Tanzania
A new AI-powered virtual reality tool helps non-experts in low-resource areas get real-time remote guidance for emergency traumatic brain injury surgery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.