Analyzing repetitive genes and their roles in cell development
Official title: Quantitative and function analysis platform for repetitive genes and gene isoforms in pluripotency regulation and differentiations
Funded at University of Michigan at Ann Arbor · NIH-10934596 · Data updated 2026-11-12
This study is looking at how certain genes work in stem cells and development, using advanced technology to get a clearer picture of these genes and their roles, which could help us understand how cells grow and change.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $672,815 |
| NIH project number | 5R01HG011469-04 |
| Project ID | NIH-10934596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to stem cell biology or developmental disorders.
✕Less likely to help
Patients with conditions unrelated to gene regulation or developmental biology may not benefit from this research.
What this research studies
This research focuses on understanding the functions of repetitive genes and gene isoforms, which play crucial roles in stem cell biology and development. By utilizing advanced sequencing techniques, the project aims to improve the accuracy of gene expression analysis and identify errors in quantifying these genes. The researchers will develop bioinformatics methods to estimate gene abundance, construct networks of gene isoforms, and predict their specific functions. This work could lead to better insights into how these genes influence cell differentiation and development.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of gene regulation in stem cells, potentially leading to improved therapies for developmental disorders.
How similar studies have gone: Previous research has shown promise in using advanced sequencing techniques to analyze gene expression, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Au, Kin Fai — University of Michigan at Ann Arbor
- Study coordinator: Au, Kin Fai
Related research
Other NIH-funded projects on the same topics.
-
Expanding genetic testing for cancer risk in patients and families
This study is working to make it easier for cancer patients in Michigan to get genetic testing for cancer risk by improving how doctors gather family history and assess genetic risks, so that more people can receive the important evaluations they need.
-
HEARTS hypertension and diabetes care in Guatemala
This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.
-
Why the retina can sometimes heal itself and how we might help it heal
This NIH grant explores how inflammation and neural cells interact in the zebrafish retina to understand retinal neuron death and regeneration, with potential implications for human vision.
-
Integrated Heart Health: A HEARTS-based approach to hypertension and diabetes in Guatemala
A study tests a team-based, stepwise care model to improve blood pressure and blood sugar control for people with both hypertension and diabetes in Guatemala.
-
Understanding how work exposures and genes influence ALS risk
A study is building a long-term group of people at higher risk for ALS to see how their jobs, exposures at work, and genes together affect if and when the disease might develop.
-
An integrated mobile health program to reduce SAVA and mental health problems among female sex workers in Kenya
A new mobile health program aims to help female sex workers in Kenya avoid substance abuse, violence, HIV, and depression by delivering group therapy, online resources, and a peer discussion space.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.