Analyzing proteins in thousands of single cancer cells each day
Official title: Advanced Sample Preparation, Separation and Multiplexed Analysis for In-Depth Proteome Profiling of >1000 Single Cells Per Day
Funded at Brigham Young University · NIH-10897109 · Data updated 2026-11-12
This study is looking at how proteins in individual cancer cells behave differently, using special technology to get detailed information that could help doctors create better, personalized treatments for patients with cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham Young University NIH-funded |
| Lab location | 1 site (Provo, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $518,183 |
| NIH project number | 5R01CA279074-02 |
| Project ID | NIH-10897109 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with various types of cancer, particularly those with heterogeneous tumors.
✕Less likely to help
Patients with early-stage cancer or those whose tumors are not accessible for single-cell analysis may not benefit from this research.
What this research studies
This research focuses on developing advanced techniques to analyze proteins in individual cancer cells, which can reveal important differences in cell behavior and characteristics. By using mass spectrometry, the study aims to profile the protein expression of over 1,000 single cells daily, providing insights that traditional bulk analysis cannot offer. This approach will help in understanding the complexity of cancer tissues and could lead to better diagnostics and treatments tailored to individual patients.
Why it matters
Potential benefit: If successful, this research could lead to more accurate cancer diagnostics and personalized treatment strategies based on the unique protein profiles of individual tumors.
How similar studies have gone: Previous research has shown promising results using similar mass spectrometry techniques for single-cell analysis, indicating a strong potential for success in this novel approach.
Where this research is happening
-
Brigham Young University
Provo, United States Active
Researchers
- Principal investigator: Kelly, Ryan T — Brigham Young University
- Study coordinator: Kelly, Ryan T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.