Analyzing kidney metabolism and its relationship with liver and heart function
Official title: Integrated multi-tissue 13C flux analysis platform to assess renal metabolism in vivo
Funded at Vanderbilt University · NIH-10727785 · Data updated 2026-11-12
This study is looking at how the kidneys, liver, and heart work together to process nutrients in the body, which could help us understand changes in metabolism related to diseases like diabetes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | August 15, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $237,750 |
| NIH project number | 1R21DK137147-01 |
| Project ID | NIH-10727785 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders, especially those related to kidney and liver function.
✕Less likely to help
Patients without metabolic disorders or those who do not have kidney or liver involvement may not benefit from this research.
What this research studies
This research aims to develop a new platform that uses 13C metabolic flux analysis to study how the kidneys, liver, and heart work together to manage nutrient metabolism in the body. By examining multiple organs simultaneously, the researchers hope to uncover important insights into how metabolic processes are regulated in living organisms. This approach will allow for a more comprehensive understanding of metabolic changes associated with diseases, particularly in conditions like diabetes. The study builds on previous work that assessed metabolic interactions in mice, paving the way for more advanced investigations.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for metabolic disorders, particularly diabetes.
How similar studies have gone: Previous studies have shown success in using metabolic flux analysis in single organs, but this multi-organ approach is novel and untested.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Young, Jamey D. — Vanderbilt University
- Study coordinator: Young, Jamey D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.