Analyzing kidney health in African American organ donors.
Official title: Trans-omics Analysis of African American Deceased Donor Kidneys for Transplant Outcomes.
Funded at Wake Forest University Health Sciences · NIH-10937567 · Data updated 2026-11-12
This study is looking at how certain genes might affect kidney health and transplant success in African Americans, hoping to find out why some people with these genes get serious kidney problems while others don’t, which could help improve kidney transplants for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $641,873 |
| NIH project number | 1R01DK140129-01 |
| Project ID | NIH-10937567 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include African American individuals with a family history of kidney disease or those who have received a kidney transplant.
✕Less likely to help
Patients who are not of African descent or those without any genetic predisposition to kidney disease may not benefit from this research.
What this research studies
This research investigates the impact of specific genetic variants in the apolipoprotein L1 gene on kidney health and transplant outcomes among African Americans. It aims to understand why some individuals with these genetic variants develop end-stage kidney disease while others do not. By examining kidney tissue from deceased donors, the study seeks to identify gene expression profiles and other factors that influence kidney transplant success. This information could help improve kidney allocation strategies and patient outcomes in transplantation.
Why it matters
Potential benefit: If successful, this research could lead to better kidney transplant outcomes for African American patients by optimizing donor kidney allocation.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors affecting kidney disease, indicating that this approach could yield valuable insights.
Where this research is happening
-
Wake Forest University Health Sciences
Winston-Salem, United States Active
Researchers
- Principal investigator: Freedman, Barry Ira — Wake Forest University Health Sciences
- Study coordinator: Freedman, Barry Ira
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.