Analyzing kidney health in African American organ donors.
Trans-omics Analysis of African American Deceased Donor Kidneys for Transplant Outcomes.
This study is looking at how certain genes might affect kidney health and transplant success in African Americans, hoping to find out why some people with these genes get serious kidney problems while others don’t, which could help improve kidney transplants for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10937567 on NIH RePORTER |
What this research studies
This research investigates the impact of specific genetic variants in the apolipoprotein L1 gene on kidney health and transplant outcomes among African Americans. It aims to understand why some individuals with these genetic variants develop end-stage kidney disease while others do not. By examining kidney tissue from deceased donors, the study seeks to identify gene expression profiles and other factors that influence kidney transplant success. This information could help improve kidney allocation strategies and patient outcomes in transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American individuals with a family history of kidney disease or those who have received a kidney transplant.
Not a fit: Patients who are not of African descent or those without any genetic predisposition to kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better kidney transplant outcomes for African American patients by optimizing donor kidney allocation.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors affecting kidney disease, indicating that this approach could yield valuable insights.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Freedman, Barry Ira — Wake Forest University Health Sciences
- Study coordinator: Freedman, Barry Ira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.