Analyzing important sugars in the body for better health insights
Development of analytical methods for glycosaminoglycans from biological sources
This study is looking at how to measure certain sugars in the body that play a big role in health and diseases, especially in brain conditions, to help us understand their importance better.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Glycan Therapeutics Corporation NIH-funded |
| Lab location | 1 site (Raleigh, UNITED STATES) |
| Project ID | NIH-10705755 on NIH RePORTER |
What this research studies
This research focuses on developing a sensitive method to analyze heparan sulfate and chondroitin sulfate, which are important sugars involved in various biological functions. By using advanced techniques like LC-MS/MS and 13C-labeled calibrants, the researchers aim to quantify these sugars in very small amounts from biological samples, including plasma and brain tissues. This could help in understanding their roles in health and diseases, particularly neurodegenerative conditions. The study will also explore the composition of these sugars to provide insights into their biological significance.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurodegenerative diseases or conditions related to blood coagulation.
Not a fit: Patients without neurodegenerative diseases or blood coagulation disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools for diseases related to blood coagulation and neurodegeneration.
How similar studies have performed: Previous research has shown success in using similar analytical methods for studying glycosaminoglycans, indicating a promising approach.
Where this research is happening
Raleigh, UNITED STATES
- Glycan Therapeutics Corporation — Raleigh, United States (Active)
Researchers
- Principal investigator: Wang, Zhangjie — Glycan Therapeutics Corporation
- Study coordinator: Wang, Zhangjie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.