Analyzing important sugars in the body for better health insights
Official title: Development of analytical methods for glycosaminoglycans from biological sources
Funded at Glycan Therapeutics Corporation · NIH-10705755 · Data updated 2026-11-12
This study is looking at how to measure certain sugars in the body that play a big role in health and diseases, especially in brain conditions, to help us understand their importance better.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Glycan Therapeutics Corporation NIH-funded |
| Lab location | 1 site (Raleigh, UNITED STATES) |
| Project start | September 15, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $988,771 |
| NIH project number | 5R44GM142304-03 |
| Project ID | NIH-10705755 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with neurodegenerative diseases or conditions related to blood coagulation.
✕Less likely to help
Patients without neurodegenerative diseases or blood coagulation disorders may not benefit from this research.
What this research studies
This research focuses on developing a sensitive method to analyze heparan sulfate and chondroitin sulfate, which are important sugars involved in various biological functions. By using advanced techniques like LC-MS/MS and 13C-labeled calibrants, the researchers aim to quantify these sugars in very small amounts from biological samples, including plasma and brain tissues. This could help in understanding their roles in health and diseases, particularly neurodegenerative conditions. The study will also explore the composition of these sugars to provide insights into their biological significance.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools for diseases related to blood coagulation and neurodegeneration.
How similar studies have gone: Previous research has shown success in using similar analytical methods for studying glycosaminoglycans, indicating a promising approach.
Where this research is happening
-
Glycan Therapeutics Corporation
Raleigh, United States Active
Researchers
- Principal investigator: Wang, Zhangjie — Glycan Therapeutics Corporation
- Study coordinator: Wang, Zhangjie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.