Analyzing immune responses to improve Zika virus vaccine design
Anti-flavivirus B cell response analysis to aid vaccine design
This study is looking at how your immune system reacts to the Zika virus to help create a safe and effective vaccine, and it may involve patients sharing samples or information to improve vaccine development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11013412 on NIH RePORTER |
What this research studies
This research focuses on understanding how the immune system responds to the Zika virus, which can cause serious health issues like Guillain-Barré syndrome. By studying the antibodies produced in response to the virus, the research aims to inform the design of a safe and effective vaccine. The approach involves analyzing the interactions between Zika virus proteins and the immune response to prevent complications that can arise from cross-reactivity with other viruses, such as dengue. Patients may be involved in providing samples or data to help refine vaccine strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been infected with the Zika virus or are at risk of infection, particularly those in areas where Zika is prevalent.
Not a fit: Patients who have no history of Zika virus exposure or live in regions where the virus is not present may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of a safe and effective vaccine against Zika virus, reducing the risk of severe complications for patients.
How similar studies have performed: Previous research on flavivirus vaccines has shown promise, indicating that this approach could lead to significant advancements in vaccine development.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Li, Yuxing — University of Maryland Baltimore
- Study coordinator: Li, Yuxing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.