Analyzing how the 3D structure of the genome changes over time
Bioinformatics Techniques to Analyze Dynamic Changes of 3D Genome
This study is all about exploring how our DNA folds and changes shape, which is important for how our genes work and how our cells stay healthy, and it's designed for anyone interested in understanding more about genetics and its impact on health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10893548 on NIH RePORTER |
What this research studies
This research focuses on understanding the three-dimensional (3D) folding of the genome and how its structure changes, which is crucial for various biological processes like gene regulation and DNA repair. The team will develop new bioinformatics tools to analyze these dynamic changes in the genome's architecture, specifically looking at patterns such as TAD splittings and stripe strengthenings. By utilizing advanced techniques like Hi-C, they aim to systematically detect and quantify these changes, providing insights into how they affect cell identity transitions. This work could lead to a better understanding of genetic regulation and its implications for health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases that may be influenced by changes in genome architecture.
Not a fit: Patients with stable genetic conditions that do not involve dynamic changes in genome structure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation, potentially leading to new treatments for genetic disorders.
How similar studies have performed: Other research has shown promise in using bioinformatics techniques to analyze genome structure, indicating that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chen, Kaifu — Boston Children's Hospital
- Study coordinator: Chen, Kaifu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.